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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6085 | PF-543 | Sphingosine Kinase 1 Inhibitor II,PF 543 | Apoptosis , S1P Receptor , Autophagy , LPL Receptor |
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM. | |||
T8461 | SKI V | Apoptosis , PI3K , S1P Receptor | |
SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces apoptosis and has antitumor activity | |||
T5891 | D-ERYTHRO-SPHINGOSINE | trans-4-Sphingenine,erythro-C18-Sphingosine,Erythrosphingosine | Phosphatase , Endogenous Metabolite , PKC |
D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator | |||
T16128 | MP-A08 | S1P Receptor | |
MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively). | |||
T4658 | MHP | Methyl caprooyl tyrosinate | S1P Receptor |
MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC. | |||
T6673 | SKI II | SphK-I2 | Apoptosis , Wnt/beta-catenin , S1P Receptor |
SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKCα, PI3K, and ERK2. | |||
T8840 | PF-543 hydrochloride | PF-543 | Apoptosis , S1P Receptor , Autophagy , LPL Receptor |
PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. | |||
T6750 | Opaganib | ABC294640 | S1P Receptor |
Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM). | |||
TQ0138 | K145 hydrochloride | Apoptosis , S1P Receptor | |
K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity. | |||
T9014 | SKI-178 | Apoptosis , S1P Receptor | |
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ... | |||
TQ0064 | Peretinoin | NIK333 | HCV Protease , Retinoid Receptor , S1P Receptor , Autophagy |
Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR. | |||
T12148 | N-Desmethyltamoxifen hydrochloride | Estrogen Receptor/ERR , Endogenous Metabolite , PKC | |
N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans. | |||
T12436 | PF-543 Citrate | Sphingosine Kinase 1 Inhibitor II Citrate | S1P Receptor |
PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ). | |||
TQ0198 | Phorbol 12-myristate 13-acetate | PMA | NF-κB , S1P Receptor , PKC |
Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13-acetate induces THP1 cell differentiation. | |||
T3148 | MK-571 sodium | L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid | Leukotriene Receptor , LTR |
MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ... | |||
T9992 | SphK1&2-IN-1 | S1P Receptor | |
SphK1&2-IN-1 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects. | |||
T63047 | SLP9101555 | S1P Receptor , LPL Receptor | |
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher than that of SphK1.SLP9101555 dramatically reduces extrace... | |||
T27710 | K6PC-5 | K6PC5,K6PC 5 | S1P Receptor |
K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated ... | |||
T23045 | N,N-Dimethylsphingosine | Others | |
sphingosine kinase (SphK) inhibitor | |||
T24803 | SKI 5C | SKI5C,SKI-5C | |
SKI 5C is a selective inhibitor of Sphingosine Kinase 1. |